In silico screening: identification of a novel CDK-1 inhibitor from Chrysophyllum cainito leaves

Authors

  • Yesudass Antony Prabhu
  • Praveen Kumar Kumar
  • Shanmughavel Piramanayagam
  • Muthu Vijayasarathy
  • Ramesh Elakiya
  • Samiappan Kavitha

Keywords:

CDK-1, Drug resistance, OSCC, Immune evasion, Novel CDK-1 inhibitors.

Abstract

Increasing evidence suggests that OSCC overexpresses CDK-1 to promote its advancement, which intervene in the paclitaxel effects. As a result of drug resistance and immune evasion, treating the advanced stage of OSCC has proven challenging. Therefore, a CDK-1 inhibitor with high inhibitory activity, excellent pharmacokinetic activities, and minimal adverse effects is urgently needed. Our study has uncovered novel CDK-1 inhibitors, which would be beneficial and expected to reinstate the paclitaxel-resistant while treating combined with our novel inhibitors in the future.    

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Published

2022-05-07

How to Cite

Yesudass Antony Prabhu, Praveen Kumar Kumar, Shanmughavel Piramanayagam, Muthu Vijayasarathy, Ramesh Elakiya, & Samiappan Kavitha. (2022). In silico screening: identification of a novel CDK-1 inhibitor from Chrysophyllum cainito leaves . International Journal of Progressive Research in Science and Engineering, 3(05), 21–24. Retrieved from https://journal.ijprse.com/index.php/ijprse/article/view/554

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Articles