Design, Synthesis, Characterization and Spectral Analysis Of 2(4-Chloro Acetamido) Benzoic Acid

Abstract

Medicinal chemistry is the study of how novel drugs can be designed and developed. This process is helped immeasurably by a detailed understanding of the structure and function of the molecular targets that are present in the body. The medicinal chemist attempts to design and synthesize a pharmaceutical agent that has a desired biological effect on human body or some other living system. In this study, Local anesthetic activity was investigated with an assumed hypothesis that the essential alkyl substituted nitrogen having strong ionization characteristics (pKa in basic side) generally found in local anesthetics can be replaced by amide nitrogen, having chloro methyl group attached to the carbonyl carbon of amide. In this type of arrangement, the inductive effect exerted by chlorine provided enough ionization character to amide nitrogen. Eight esters, ten amides and one imidazole derivatives of 4-(2-chloroacetamido) benzoic acid were synthesized by Fischer’s esterification, Schotten-Baumann and substitution reactions. Local anesthetics are the drugs which produce reversible block of nerve damage without loss of consciousness and with loss of pain sensation.